Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HCV infection with one or more nucleotide analogs.本發明揭示核苷酸類似物,合成核苷酸類似物之方法,及用一或多種核苷酸類似物治療諸如HCV感染之疾病及/或病況的方法。