Disclosed herein are nucleosides, nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Filoviridae virus infection with one or more nucleosides and/or nucleotide analogs.本發明揭示核苷、核苷酸類似物、合成核苷酸類似物之方法及使用一或多種核苷及/或核苷酸類似物治療諸如絲狀病毒科(Filoviridae)病毒感染之疾病及/或病狀的方法。