GUIDUCCI, Cristiana,NAIK, Edwina,MILLEY, Robert,CHIPMAN, Stewart
申请号：
SG11201808913W
公开号：
SG11201808913WA
申请日:
2017.04.14
申请国别(地区):
SG
年份:
2018
代理人:
摘要：
The present disclosure relates to methods for treating cancer by intratumoral delivery of particles containing a Toll-like receptor 9 agonist (TLR9) and a tumor antigen, in which the TLR9 agonist is a polynucleotide or a chimeric compound thereof. The methods of the present disclosure involve injection of the particles into at least one tumor, and are effective for treating both injected and uninjected tumors of a mammalian subject. Additionally, the present disclosure provides immunogenic compositions containing the particles, as well as methods of manufacture thereof.
