Cristiana GUIDUCCI,Edwina NAIK,Robert J. MILLEY,Stewart D. CHIPMAN
申请号：
US15488353
公开号：
US20170326232A1
申请日:
2017.04.14
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present disclosure relates to methods for treating cancer by intratumoral delivery of particles containing a Toll-like receptor 9 agonist (TLR9) and a tumor antigen, in which the TLR9 agonist is a polynucleotide or a chimeric compound thereof. The methods of the present disclosure involve injection of the particles into at least one tumor, and are effective for treating both injected and uninjected tumors of a mammalian subject. Additionally, the present disclosure provides immunogenic compositions containing the particles, as well as methods of manufacture thereof.
