New benzothiophenes and benzofurans substituted at position 2 with heteroaryl

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专利权人:

AstraZeneca AB

发明人:

ARZEL, Erwan,SWAHN, Britt-Marie,WENSBO, David

申请号：

ES08724190

公开号：

ES2615381T3

申请日:

2008.03.05

申请国别(地区):

ES

年份:

2017

代理人:

摘要：

A compound according to formula Ia ** Formula ** in which R1 is selected from H, halo, methyl, C1-10 fluoroalkyl, C1-3 alkylene C1-3alkyl, C1-3 alkylene C1-3fluoroalkyl, C1- alkylene 3NH2, C1-3N alkylene C1-3alkyl, C1-3N alkylene (C1-3 alkyl) 2, C1-3N alkyleneFluoroalkyl C1-3, C1-3N alkylene (C1-3 fluoroalkyl) 2, C1-3N alkylene (C1- alkyl 3) C1-3 fluoroalkyl, hydroxy, methoxy, C1-5 fluoroalkoxy, C1-5 alkylthio, C1-5 fluoroalkyl, amino, NH3-3alkyl, NHfluoroalkyl C1-3, N (C1-3alkyl) 2, N (alkyl C1-3) C1-3 fluoroalkyl, NH (CO) C1-3 alkyl, NH (CO) C1-3 fluoroalkyl, NH (CO) C1-3 alkoxy, NH (CO) C1-3 fluoroalkoxy, NHSO2 C1-3 alkyl, NHSO2 C1-3 fluoroalkyl, (CO) C1-3 alkyl, (CO) C1-3 fluoroalkyl, (CO) C1-3 alkoxy, (CO) C1-3 fluoroalkoxy, (CO) NH2, (CO) NH C1-3alkyl, (CO) C1-3 NHfluoroalkyl, (CO) N (C1-3 alkyl) 2, (CO) N (C1-3 alkyl) C1-3 fluoroalkyl, (CO) N (C4-6 alkylene), (CO) N (C4-6 fluoroalkylene), silt, SO2NHfluoroalkyl C1-3, nitro and SO2NH2； R2 is selected from H, halo, methyl, C1-5 fluoroalkyl, C1-3 alkylene C1-3alkyl, C1-3 alkylene C1-3fluoroalkyl, C1-3NH2 alkylene, C1-3N alkylene C1-3N alkylene, C1-3N alkylene C1-3 alkyl) 2, C1-3N alkyleneHl3-3 fluoroalkyl, C1-3N alkylene (C1-3 fluoroalkyl) 2, C1-3N alkylene (C1-3 alkyl) C1-3 fluoroalkyl, hydroxy, methoxy, C1-5 fluoroalkoxy , C1-5 alkylthio, C1-5 fluoroalkylthio, amino, NH C1-3alkyl, NHfluoroalkyl C1-3, N (C1-3alkyl) 2, N (C1-3alkyl) fluoroalkyl C1-3, NH (CO) C1alkyl -3, NH (CO) C1-3 fluoroalkyl, NH (CO) C1-3 alkoxy, NH (CO) C1-3 fluoroalkoxy, NHSO2 C1-3 alkyl, NHSO2fluoroalkyl C1-3, (CO) C1-5 alkyl, ( CO) C1-3 fluoroalkyl, (CO) C1-3 alkoxy, (CO) C1-3 fluoroalkoxy, (CO) NH2, (CO) NH3-3alkyl, (CO) NHfluoroalkyl C1-3, (CO) N (alkyl C1-3) 2, (CO) N (C1-3 alkyl) C1-3 fluoroalkyl, (CO) N (C4-6 alkylene), (CO) N (C4-6 fluoroalkylene), cyano, SO2NHfluoroalkyl C1-3, nitro and SO2NH2； or R1 and R2 together form a ring； ** Formula ** X9 is selected from O and S. Q is an aromatic nitrogen-containing heterocycle selected fro

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