A balloon catheter for delivering a combination of pharmaceutical active agents to a diseased blood vessel or conduit comprising an exterior coating layer of hydrophobic drugs with a first therapeutic agent is an mTor inhibitor and a second is an NF-kβ inhibitor. The pharmaceutical composition for treating proliferative diseases is further comprised of a mixture of two hydrophobic therapeutic agents coated on a medical device, with a first therapeutic agent is an mTor inhibitor and the second therapeutic agent is an NF-kβ inhibitor. The device and pharmaceutical combination comprise a method for treating proliferative diseases.
