Relates to pharmaceutical compositions having both persistence and fast-acting, are surface coated with water-insoluble polymer, the present invention, the pharmaceutically active ingredient a sustained release portion comprising a pharmaceutical acceptable carrier controlled-release base on pharmaceutical composition comprising a quick release portion comprising a pharmaceutical acceptable carrier pharmaceutically active ingredient. The pharmaceutical composition of the present invention, by applying a water-insoluble polymer to the surface of the controlled release portion and a pharmaceutical acceptable carrier and a controlled-release base with a pharmaceutical active ingredient, can be separated from the quick-dissolving part, shows the release profile of the sustained release portion and a discharge portion is an independent speed, limited and not in the content and type of the available pharmaceutical active ingredient, and can be produced in a relatively simple process. [Selection] Figure Figure 1本発明は、速効性と持続性を同時に有する薬剤学的組成物に関し、水不溶性ポリマーで表面塗布されており、薬学的活性成分;放出制御基剤;薬学的許容担体を含む徐放部と、薬学的活性成分;薬学的許容担体を含む速放部とを含む薬剤学的組成物に関する。本発明の薬剤学的組成物は、薬学的活性成分と放出制御基剤と薬学的許容担体とを含む徐放部の表面を水不溶性ポリマーで塗布することにより、速放部と分離して、速放部と徐放部が独立した放出特性を示し、使用可能な薬学的活性成分の含有量と種類に制限がなく、かつ、比較的簡単な工程で製造可能である。【選択図】図1
