James D. Marks,Maria Consuelo Garcia Rodriguez,Shude Yan
申请号:
US14966959
公开号:
US09902781B2
申请日:
2015.12.11
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.