Lakshmi Krishnan;Dennis M. Whitfield;Dennis Sprott
发明人:
Dennis Sprott,Dennis M. Whitfield,Lakshmi Krishnan
申请号：
US12225381
公开号：
US08936793B2
申请日:
2007.03.30
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Archaeal lipid adjuvants are synthesized by chemically coupling various carbohydrates or anionic polar groups to the free hydroxyl(s) of archaeal lipid cores. Chemically stable lipid cores such as saturated archaeol and caldarchaeol are obtained from appropriate Archaea. Archaeosome lipid vesicles are formulated from the synthetic lipids selected to serve as antigen carriers that target antigen-presenting cells and promote an appropriate immune response to the antigen.
