A method for enhancing uptake of a therapeutic agent from the bloodstream of a patient into a disease site of the patient includes applying negative pressure to the disease site to form a pressure differential favorable for transport of the therapeutic agent from the bloodstream into the disease site. A system for enhancing uptake of therapeutic agent from the bloodstream of a patient into a disease site of the patient includes (a) a partial enclosure with edge configured to interface with an exposed surface, of the patient and overlying the disease site, to seal the partial enclosure to the exposed surface, and (b) a pump for evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure, to apply a negative pressure to the disease site so as to enhance uptake of the therapeutic agent into the disease site.
