A method, for enhancing uptake, into a disease site, of therapeutic agent administered to the bloodstream, includes sealing a partial enclosure to the patient at the disease site, administering the therapeutic agent to the bloodstream at a first time, and evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure at a second time that is after the first time by a first delay. A system, for enhancing uptake, into a disease site, of therapeutic agent administered to the bloodstream, includes a first partial enclosure configured to seal to an exposed surface overlying the disease site, a pump configured to produce a partial vacuum in the first partial enclosure to enhance the uptake of the therapeutic agent, and a control module for controlling delay between delivery of the therapeutic agent to the bloodstream and production of the partial vacuum.
