Galderma Research &； Development;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
Rachel AUZELY-VELTY,Tamiris FIGUEIREDO,Laura JING JING,Craig Steven HARRIS,Jean-Guy BOITEAU,Thibaut GERFAUD,Loic TOMAS
申请号：
US16322653
公开号：
US20200002441A1
申请日:
2017.08.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A new hydrogel made of double crosslinked glycosaminoglycans, particularly crosslinked hyaluronic acid, chondroitin or chondroitin sulfate, having reversible linkages using boronic acid or boroxole derivatives leading to new benefits. Double crosslinked glycosaminoglycans, one linkage via two ether bonds with a hydroxyl group of each of two glycosaminoglycans and another linkage via an alkoxyboronate ester anion formed between a boronate hemiester grafted to one of the glycosaminoglycans and a diol function of to the other glycosaminoglycan. The diol function may be a backbone diol function or a diol portion of a diol functional moiety grafted the other glycosaminoglycan.
