The compound represented by the following formula (I) and the like have PAI-1 inhibition activity； wherein: R 1 represents a C 6-10 aryl group which may be substituted or the like； T represents a single bond or the like； m represents 0 or 1； when m is 0, G represents -N-C(=O)-CO 2 H or the like； when m is 1, G represents an oxygen atom or the like； R 2 represents a C 6-10 aryl group which may be substituted or the like； E represents the following formula (II) wherein one of R 31 , R 32 , R 33 and R 34 represents the formula R 1 -T-, each of the other three independently represents a hydrogen atom or the like, and R 35 represents the formula -X-Y', a hydrogen atom or the like； X represents -CH 2 - or the like； Y' represents a carboxy group or the like； M represents a single bond or the like.
