A self-aligning system for coupling a catheter to a rotational drive assembly includes a catheter and a drive assembly. The catheter includes an elongate catheter body, a rotatable driveshaft extending within the elongate catheter body, a connector at a proximal end of the elongate catheter body, and a keyed feature extending from an outer diameter of the connector. The drive assembly includes a motor configured to rotate the driveshaft, a receiving tube with a distal opening configured to receive the connector, and a channel on an inner surface of the receiving tube, the channel including two opposing curved walls that are angled towards a substantially straight section. The keyed feature is configured to slide against one of the opposing curved walls and into the substantially straight section to rotationally align the proximal end of the catheter with the drive assembly.
