Susan E. Lacy,Lorenzo Benatuil,Meha Chhaya,Emma Fung,Renee Miller,Ravi Chari,Sarah J. Heighton,Jacqueline G. Bixby
申请号：
US13940506
公开号：
US09670276B2
申请日:
2013.07.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of IL-1α and/or IL-1β and can be used for the treatment immunological diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, multiple sclerosis, and other autoimmune diseases. In addition, their uses in the amelioration and/or treatment of pain in an individual suffering from a disease or disorder associated with IL-1 accumulation.
