The present invention relates to a compound of formula (I)wherein W is CH, C(R) or N； X is CH or CCl； Y is CH； Z is C(R)； Rand Rare hydrogen； Rand Rare each independently halo or a group selected from Calkyl, Calkoxy, cycloalkyl, aryl and heteroaryl, any of which is optionally substituted with 1, 2 or 3 R, said cycloalkyl having 3, 4, 5 or 6 ring atoms, 1 or 2 of which are heteroatoms, selected from N, O or S； Rand Rtaken together with the carbon atom to which they are attached may form a 5- or 6-membered heterocycle, containing 1 or 2 nitrogen atoms as heteroatoms, which is optionally substituted with 1 or 2 R； each Ris independently selected from halogen, trifluoromethyl, cyano, oxo, nitro, -OR, -C(O)R, -C(O)OR, -OC(O)R, -S(O)R, -N(R)R, -N(R)C(O)R, -C(O)N(R)R, -S(O)N(R)Rand R； Rand Rare each independently hydrogen or R； Ris selected from Calkyl, cycloalkyl, aryl, cycloalkyl-Calkyl and heteroaryl, any of which is optionally substituted with 1, 2 or 3 substituents, independently selected from halogen, cyano, amino, hydroxy, Calkyl, Calkoxy, said cycloalkyl having 3, 4, 5 or 6 ring atoms, sail aryl being phenyl and said heteoaryl having 5 or 6 ring atoms, 1 or 2 of which are heteroatoms, selected from N, O or S； l=0, 1 or 2； m=2； n=1 or 2； or a pharmaceutically acceptable salt or N-oxide thereof； with the proviso that said compound is not one of the following compounds: -8-(3-fluoropyridine-4-yl)-2-(trans-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one； -[2-(2,6-diethylphenyl)-4-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-6-methylpyrimidine-5-ylmethyl]methyl-(1S)-(1,2,3,4-tetrahydronaphthalene-1-yl)amine； -(5R)-7-(3-fluoropyridine-4-yl)-2-(trans-4-hydroxycyclohexyl)-2,7-diazaspiro[4.5]decan-1-one and -7-(3-fluoropyridine-4-yl)-2-(4-hydroxy-1-adamantyl)-2,7-diazaspiro[4.5]decan-1-one, pharmaceutical compositions comprising these compounds and their potential use as therapeutic agents for the treatment and/or prevention of cancer.Настоящее изобретение относится к формулы (
