Tetrahydroisoquinolin-1-one derivative or salt thereof

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专利权人:

Seldar Pharma Inc.

发明人:

Hiroyuki Hisamichi,Itsuro Shimada,Tsukasa Ishihara,Tomofumi Takuwa,Takafumi Shimizu,Noriko Ishikawa,Kyoichi Maeno,Norio Seki

申请号：

US13942158

公开号：

US09150541B2

申请日:

2013.07.15

申请国别(地区):

US

年份:

2015

代理人:

摘要：

To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-1-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-1-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.

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中国工程科技知识中心

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http://www.ckcest.cn/home/