DUPONT PASSELAIGUE ELISABETH,LE ROY ISABELLE,PIGNIER CHRISTOPHE
申请号：
IN3938/DELNP/2013
公开号：
IN2013DN03938A
申请日:
2013.05.02
申请国别(地区):
IN
年份:
2014
代理人:
摘要：
The present invention concerns derivatives of heteroarylsulfonamides notably as blockers of Kv potassium channels and more particularly of channels Kv1.5 Kv4.3 or Kv11.1 their application in clinical therapy and their preparation methods. These compounds correspond to the following general formula (I): where R1 represents one or more substituents of the phenyl core X such as: hydrogen halogen trifluoromethyl trifluoromethoxy linear or branched C C alkyl or linear or branched C C alkoxy A represents oxygen or sulphur B represents nitrogen when n=1 or 2 and D represents -C(=O) or B represents CH when n=0 and D represents -CHO- or when n=1 and D represents -O- R2 represents a hydrogen a methyl a fluorine or chlorine atom or a methoxy HetAr represents a pyridyl or quinolyl group possibly substituted by a group such as a linear or branched C C alkyl a linear or branched C C alkoxy a halogen or a trifluoromethyl and to their pharmaceutically acceptable salts.
