The present invention discloses an application of Antrodia cinnamomea in prevention and treatment of hypertropic cardiomyopathy and myocardial fibrosis. One embodiment of the present invention is an application of an extract of Antrodia cinnamomea or the fruiting body of Antrodia cinnamomea as one of the followings: (A) manufacturing a product for preventing and/or treating hypertropic cardiomyopathy and/or myocardial fibrosis； (B) preventing and/or treating hypertropic cardiomyopathy and/or myocardial fibrosis. Antrodia cinnamomea can effectively suppress the increase in a heart-to-body weight ratio and a heart-weight-to-tibia-length ratio of an organism body caused by hypertropic cardiomyopathy, and suppress the increase in ANF gene expression in myocardial tissue, such that the increase in myocardial collagen volume fraction of the organism body caused by myocardial fibrosis and the increase in myocardial fibrosis marker gene expression of collagen 1, collagen 3 in myocardial tissue can be effectively suppressed as well. It can be shown that Antrodia cinnamomea have important effects in prevention and treatment of hypertropic cardiomyopathy and myocardial fibrosis.本發明公開了牛樟芝在防治心肌肥大及心肌纖維化中的應用。本發明所提供的應用具體為牛樟芝或牛樟芝的子實體提取物在如下(A)或(B)中的應用：(A)製備用於預防和/或治療心肌肥大和/或心肌纖維化的產品；(B)預防和/或治療心肌肥大和/或心肌纖維化。牛樟芝能夠使得由於心肌肥大引起的機體心臟體重比和心臟脛骨比升高、心肌組織中ANF基因的表達水準升高均得到有效抑制；使得由於心肌纖維化引起的機體心肌膠原容積分數升高、心肌組織中心肌纖維化標誌基因Collagen1和Collagen3的表達水準升高也均得到有效抑制。可見牛樟芝對於防治心肌肥大和心肌纖維化具有重要作用。
