Inc.;Regents of the University of Minnesota;Dana-Farber Cancer Institute;Dana-Farber Cancer Institute, Inc.
发明人:
Bradner, James E.,Blazar, Bruce,Flynn, Ryan,Qi, Jun
申请号：
AU2015342895
公开号：
AU2015342895A1
申请日:
2015.11.06
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises administering to a subject in need thereof a EZH2 inhibitor, a Bcl6 inhibitor and/or BRD4 inhibitor. The present disclosure is based, at least in part, on the discovery that enhancer of zeste homolog 2 (EZH2) inhibitors, B-cell lymphoma 6 protein (Bcl6) inhibitors and/or bromodomain-containing protein 4 (BRD4) inhibitors can be used to treat chronic graft versus host disease (cGVHD).
