BRADNER, JAMES E.,BLAZAR, BRUCE,FLYNN, RYAN,QI, JUN
申请号：
CA2966336
公开号：
CA2966336A1
申请日:
2015.11.06
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
In some aspects, the instant disclosure relates to methods of treating chronic graft versus host disease (cGVHD). In some embodiments, the method comprises administering to a subject in need thereof a EZH2 inhibitor, a Bcl6 inhibitor and/or BRD4 inhibitor. The present disclosure is based, at least in part, on the discovery that enhancer of zeste homolog 2 (EZH2) inhibitors, B-cell lymphoma 6 protein (Bcl6) inhibitors and/or bromodomain-containing protein 4 (BRD4) inhibitors can be used to treat chronic graft versus host disease (cGVHD).
