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Vitamin D receptor/SMAD genomic circuit gates fibrotic response
专利权人:
The University of Sydney;Salk Institute for Biological Studies
发明人:
Ding, Ning,Downes, Michael,Liddle, Christopher,Evans, Ronald M.
申请号:
AU2014257051
公开号:
AU2014257051A1
申请日:
2014.04.24
申请国别(地区):
AU
年份:
2015
代理人:
摘要:
The present disclosure provides compositions that include a nanoparticle and a compound that increases the biological activity of the vitamin D receptor (VDR) (e.g., a VDR agonist), and methods of using such compounds to increase retention or storage of vitamin A, vitamin D, and/or lipids by a cell, such as an epithelial or stellate cell. Such methods can be used to treat or prevent fibrosis.
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