RS ARASTIRMA EGITIM DANISMANLIK ILAC SANAYI TICARET ANONIM SIRKETI
发明人:
申请号：
IL26659319
公开号：
IL266593D0
申请日:
2019.05.13
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
A polymer-drug conjugate of Formula I for delivery of therapeutic agents； Wherein R1, R2 and R3 are independently selected from H or methyl； x and y are independently a number between 1-100； n is a number between 1-50； L is a cleavable linker； A and B are independently an end group or null； and D is a therapeutic agent slected from combretasatin, 5-fluorouracil, gemcitabine, chlorquine, and doxorubicin. The linker may be selected from a polyethylene glycol, an amino acid, poly amino acids, short peptides and an optionally substituted C1-10 hydrocarbon comprising a physiologically labile functional group. Polymeric assemblies formed with polymer drug conjugates of Formula I are claimed. The polymeric assembly may encapsulate additional therapeutic agents. Methods of preparing a polymer drug conjugate of Claim 1 are also claimed wherein the methods first comprise polymerizing a PEG grafted or PEG methyl ester grafted acrylate or methacrylate monomer to form a brush block copolymer. Pharmaceutical compositions comprising the polymer drug conjugate or polymeric assemblies thereof are also claimed. Claims to the polymer drug conjugate, polymeric assemblies and compositions thereof for use in the treatment or prophylaxis of cancer are also provided.
