FERGUSON, ELAINE,THOMAS, DAVID WILLIAM,DESSEN, ARNE,RYE, PHILIP
申请号：
CA3040796
公开号：
CA3040796A1
申请日:
2017.10.20
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides abacitracin-alginate oligomer conjugate comprising a bacitracin-class antibiotic connected covalently to at least one alginate oligomer via a direct covalent bond or a covalent molecular linker, or a pharmaceutically acceptable salt, solvate, hydrate, diastereoisomer, tautomer, enantiomer or active metabolite thereof. Also provided are methods for the preparation of said conjugate, pharmaceutical compositions comprising said conjugate and the use thereof in a method for the treatment or prevention of a bacterial infection in a subject with, suspected to have, or at risk of, a bacterial infection.
