The Trustees of Columbia University in the City of New York
发明人:
Filippo MANCIA,Vasileios PETROU,Oliver B. CLARKE,Jeremie P. VENDOME
申请号：
US15775674
公开号：
US20190231747A1
申请日:
2016.11.14
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention relates to identification of inhibitors or antagonists of aminoarabinase glycosyltransferase (ArnT) and their use in compositions, methods of treatment or prevention of drug resistant gram negative infections, or inhibiting the growth of gram negative bacterial infections resistant to polymyxin-class antibiotics. In certain aspects, the inhibitors or antagonists can be administered in combination with one or more antibacterial agents.
