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COMPOSES MODULATEURS DE TRPV1
专利权人:
S.L.;ANTALGENICS
发明人:
DEVESA GINER, ISABEL,GENAZZANI, ARMANDO,PIRALI, TRACEY,FERNANDEZ CARVAJAL, ASIA,FERRER MONTIEL, ANTONIO VICENTE
申请号:
CA3062592
公开号:
CA3062592A1
申请日:
2018.05.10
申请国别(地区):
CA
年份:
2018
代理人:
摘要:
The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically, veterinary or cosmetically acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6' are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloal kyI, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12) heteroaryI, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.
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