Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators农业专利-农业专业知识服务系统

摘要：: ABSTRACT - 600355 Discloses herein is a stable blend comprising (i) a compound selected from 2-amino-2-[2-( 4-octylphenyl) ethyl]propane-1,3-diol (FTY720) in free form, a pharmaceutically acceptable salt thereof, FTY720-phosphate, 1-{ 4-[1-( 4-cyclohexyl-3-trifluoromethyl-benzyloxyim i no )-ethyl]-2-ethyl-benzyl} -azetidine-3-carboxylix acid, and (ii) one or more of the following excipients: (a) Fillers selected from lactose monohydrate, lactose anhydrous, maize starch, sorbitol, sucrose, microcrystalline cellulose, dibasic calcium phosphate, maltodextrin, gelatin and/or (b) Binders selected from HPMC, L-HPC, povidone, HPC and/or (c) Disintegrants selected from maize starch, crospovidone, croscarmellose sodium, sodium carboxymethylstarch, pregelatinized starch, calcium silicate and/or (d) Lubricants selected from hydrogenated castor oil, glycerol behenate, magnesium stearate, calcium stearate, zinc stearate, mineral oil, silicone fluid, sodium lauryl sulfate, L- leucine, sodium stearyl fumarate, and/or (e) Flow regulators selected from colloidal silicone dioxide, talc and/or (f) Matrix formers selected from hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, pullulan, starch, povidone and/or (g) Plastisizers selected from PEG 400, Dibutyl sebacate, sorbitol and/or (h) Flavoring agents selected from menthol, tutti fruit and/or (i) Sweeteners selected from sucralose, sodium saccharine.