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Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
- 专利权人:
- NOVARTIS AG
- 发明人:
- RUEGGER COLLEEN,AMBUHL MICHAEL
- 申请号：
- NZ62868608
- 公开号：
- NZ628686A
- 申请日:
- 2008.10.09
- 申请国别(地区):
- NZ
- 年份:
- 2016
- 代理人:
- 摘要：
- Discloses herein is a stable binary blend of a pharmaceutical composition for oral administration, which comprises: (i) a compound selected from 2-amino-2-[2-(4-octylphenyl) ethyl]propane-1,3-diol (FTY720) in free form, a pharmaceutically acceptable salt thereof, FTY720-phosphate, 1-{ 4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl} -azetidine-3-carboxylix acid, and (ii) one excipient selected from the group consisting of: Lactose, Hydroxypropyl methylcellulose (HPMC), Hydroxypropylcellulose (HPC), Crospovidone, Croscarmellose sodium, starch, and Colloidal silicone dioxide the blend may optionally comprise further ingredients selected from: (b) Binders selected from HPMC, L-HPC, povidone, HPC, (c) Disintegrants selected from maize starch, crospovidone, croscarmellose sodium, sodium carboxymethylstarch, pregelatinized starch, calcium silicate, (d) Lubricants selected from hydrogenated castor oil, glycerol behenate, magnesium stearate, calcium stearate, zinc stearate, mineral oil, silicone fluid, sodium lauryl sulfate, L- leucine, sodium stearyl fumarate, (e) Flow regulators selected from colloidal silicone dioxide, talc, (f) Matrix formers selected from hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, ethyl cellulose, pullulan, starch, povidone, (g) Plastisizers selected from PEG 400, Dibutyl sebacate, sorbitol, (h) Flavoring agents selected from menthol, tutti fruit, and (i) Sweeteners selected from sucralose, sodium saccharine.
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
