Jane Spetzler,Lauge Schaeffer,Jesper Lau,Thomas Kruse,Patrick William Garibay,Soeren Oestergaard,Steffen Reedtz-Runge,Henning Thoegersen
申请号：
US13930079
公开号：
US09067977B2
申请日:
2013.06.28
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to protracted peptide derivatives such as Glucagon-Like Peptide-1 (GLP-1), exendin-4, and analogs thereof, as well as therapeutic uses thereof. The peptide derivative of the invention comprises a peptide wherein at least one amino acid residue is derivatized with A-B-C-, or A-B-C-D-. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, have a low ratio of binding affinity to the GLP-1 receptor in the presence of high/low albumin concentrations, have long half-lives, and have a high affinity of binding to albumin, all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.
