Ying WANG,Irini AKRITOPOULOU-ZANZE,Frauke POHLKI,Jason T. BREWER,Stevan W. DJURIC,Wilfried BRAJE,Ana- Lucia RELO
申请号：
MX2016002648
公开号：
MX347948B
申请日:
2010.10.21
申请国别(地区):
MX
年份:
2017
代理人:
摘要：
The present application relates to 1,2,3,4)4a,5,6,7-octahydropyraziÏ€o[1,2- a ][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1)2-a][1,5]benzodiaze pine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d(][2] benzazepine, 1,2,3,4,4a,5,6,7- octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2- a ][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]ben zoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-6] [1,4]diazepine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.La presente solicitud se refiere a derivados de 1,2,3,4)4a,5,6,7-octahidropirazino[1 ,2-a][1 ,4]benzodiazepina, 1,2,3,4,4a,5,6,7-octahidropirazino[1)2-a][1,5]benzodiazepina,2,3, 4,4a,5,6,7,11b-octahidro-1H-pirido[3,4-d(][2]benzazepina,1,2,3,4, 4a,5,6,7-octahidropirazino[1,2-a)[1]benzazepina,1,2,3,4,4a,5-hexa hidro-7H-pirazino[1,2-a][4,1]benzoxazepina, y 2,3,4,4a,5,6-hexahidro-1H-pirazino[2,1-d][1,5]benzoxazepina, y 5,6,7,7a,8,9,10,11-octahidropirazino[1,2-d]pirido[3,2-6][1,4]diaz epina de la fórmula (I) en la cual R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, y Y3 son como se definen en la descripción. La presente solicitud también se refiere a composiciones que comprenden dichos compuestos, y a métodos para tratar condiciones patológicas utilizando dichos compuestos y composiciones, y a métodos para identificar dichos compuestos.
