PROCEDE DE FABRICATION DE CRISTAUX D'ACIDE 2-(3-CYANO-4-ISOBUTYLOXYPHENYL)-4-METHYL-5-THIAZOLE­CABOXYLIQUE POLYMORPHIQUE PAR UNE METHODE D'ADDITION D'UN SOLVANT MEDIOCRE

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专利权人:

TEIJIN PHARMA LIMITED

发明人:

UEMURA, AKIHITO,NOGATA, TOMOAKI,TAKEYASU, TAKUMI

申请号：

CA2764603

公开号：

CA2764603C

申请日:

2010.07.14

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Disclosed is a process for producing A-form crystals of2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic acid,comprising: a stepof dissolving by heating 2-(3-cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylicacid in one or a plurality of solvents as a good solvent, selected from thegroup consistingof 1-propanol, 2-propanol, ethanol, and acetone； a step of cooling thesolution； and a stepof adding to the solution a hydrocarbon solvent as a poor solvent.

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