Matthew J. Bernett,John R. Desjarlais,Sher Bahadur Karki,Gregory Alan Lazar,Umesh S. Muchhal,Duc-Hanh Thi Nguyen,John O. Richards
申请号：
US12441885
公开号：
US08394374B2
申请日:
2007.09.18
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
