Matthew J. Bernett,John R. Desjarlais,Sher Bahadur Karki,Gregory Alan Lazar,Umesh S. Muchhal,Duc-Hanh Thi Nguyen,John O. Richards
申请号：
US13794676
公开号：
US09040042B2
申请日:
2013.03.11
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.
