NATIONAL RESEARCH COUNCIL OF CANADA;YM BIOSCIENCES INC.
发明人:
TIKHOMIROV, ILIA ALEXANDRE,JARAMILLO, MARIA L.,O'CONNOR-MCCOURT, MAUREEN D.,SULEA, TRAIAN,GILBERT, RENALD,GAILLET, BRUNO,BAARDSNES, JASON,BANVILLE, MYRIAM,GROTHE, SUZANNE,OCONNOR-MCCOURT, MAUREEN D.
申请号：
EP12738907
公开号：
EP2668209A4
申请日:
2012.01.20
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
