KOSKI, Gary, K.,DATTA, Jashodeep,CZERNIECKI, Brian, J.
申请号：
EP15761155
公开号：
EP3129034A4
申请日:
2015.03.13
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer CD4+ Th1 response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of said subjects blood which causes secretion of interferon-gamma (&ldquoIFN-&gamma&rdquo) and detecting said anti-cancer CD4+ Th1 response to determine if said response is depressed. A method for restoring HER2-specific CD4+ Th1 immune response in a HER2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell (&ldquoDC&rdquo) vaccine comprising autologous DCs pulsed with HER2-derived MHC class II binding peptides (&ldquoDC vaccination&rdquo) to elevate said patients anti-HER2 CD4+ Th1 response and measuring said anti-HER2 Th1 response of said patient pre- and post-DC vaccination to determine the amount of increase in said response.
