Czerniecki, Brian J.,Koski, Gary K.,Datta, Jashodeep
申请号：
AU2016244182
公开号：
AU2016244182B2
申请日:
2016.10.10
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2016244182B220181220.pdf#####ABSTRACT OF THE DISCLOSURE A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer CD4+ ThI response from antigen presenting cells or their precursors and CD4+ T-cells from a sample of said subject's blood which causes secretion of interferon-gamma ("IFN-y")； and detecting said anti-cancer CD4+ ThI response to determine if said response is depressed. A method for restoring HER2-specific CD4+ Th1 immune response in a HER2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell ("DC") vaccine comprising autologous DCs pulsed with HER2-derived MHC class II binding peptides ("DC vaccination") to elevate said patient's anti-HER2 CD4+ Th1 response； and measuring said anti-HER2 Th1 response of said patient pre- and post-DC vaccination to determine the amount of increase in said response.N I~ ik jon [C"? No 15 LJ~ cyc ThTh CCD 'KR jcloy n 'n ..h ...a' 11L~O"T~ I: "Pit.______ 71f "1 ~Tt AL'tu r 0 iK 2 ~t13 C MV~~ ~ sxt~~ Ltc !9Q, 3ZNK$(C t ua~~~ qra a I 'N N" "N" "N' "N"
