THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人:
MALEKZADEH, PARISA,ROSENBERG, STEVEN A.,DENIGER, DREW C.
申请号：
CA3080274
公开号：
CA3080274A1
申请日:
2018.09.17
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Disclosed are methods of isolating T cells having antigenic specificity for a mutated p53 amino acid sequence encoded by a cancer-specific p53 mutation, the method comprising: inducing autologous APCs of the patient to present the mutated p53 amino acid sequence； co-culturing autologous T cells of the patient with the autologous APCs that present the mutated p53 amino acid sequence； and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
