The United States of America;as represented by the Secretary;Department of Health and Human Services
发明人:
Drew C. Deniger,Steven A. Rosenberg,Parisa Malekzadeh
申请号：
US16650696
公开号：
US20200316121A1
申请日:
2018.09.17
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed are methods of isolating T cells having antigenic specificity for a mutated p53 amino acid sequence encoded by a cancer-specific p53 mutation, the method comprising: inducing autologous APCs of the patient to present the mutated p53 amino acid sequence； co-culturing autologous T cells of the patient with the autologous APCs that present the mutated p53 amino acid sequence； and selecting the autologous T cells. Also disclosed are related methods of preparing a population of cells, populations of cells, pharmaceutical compositions, and methods of treating or preventing cancer.
