The present application provides a complex bone cement including a powder mixture and an aqueous solution. The powder mixture includes calcium sulfate and a calcium phosphate salt. The aqueous solution includes water, collagen and a pharmaceutical ingredient in effective dose. By adding collagen and the pharmaceutical ingredient to the aqueous solution of the bone cement, the drug will release in a long-acting manner and induce differentiation of osteoblast as well as the healing of bone defects.本發明提出一種複合性骨水泥,其包含一粉劑及一水劑,其中該粉劑包含硫酸鈣及一鈣磷酸鹽;該水劑包含水、膠原蛋白及有效量之一醫藥成分。透過添加膠原蛋白及該醫藥成分於骨水泥之水劑中,能夠使該醫藥成分具備緩釋的效果,且有助於硬骨細胞分化及骨缺損的修補。
