MODEL SYSTEM FOR MITOCHONDRIAL DYSFUNCTION AND METHODS OF USING THE SAME

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专利权人:

The UAB Research Foundation

发明人:

Keshav K SINGH

申请号：

US16573705

公开号：

US20200085021A1

申请日:

2019.09.17

申请国别(地区):

US

年份:

2020

代理人:

摘要：

A transgenic non-human animal model is disclosed. The system comprises an inducible transgene allowing the expression of a mutant POLG1 polypeptide that results in modulation of mitochondrial DNA copy number and/or concentration in the whole transgenic non-human animal or selected cells or tissues of the transgenic non-human animal. Methods of producing and using the model system are also provided.

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中国工程科技知识中心

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http://www.ckcest.cn/home/