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TRANSGENIC MOUSE MODEL FOR CONDITIONAL FKBP51 EXPRESSION AND RELATED METHODS
专利权人:
Chad Dickey
发明人:
Chad Dickey,Bo Zhang,Laura Jenelle Blair
申请号:
US15602985
公开号:
US20170258940A1
申请日:
2017.05.23
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The subject invention pertains to transgenic non-human animals comprising a transgenic nucleotide sequence, integrated into the genome of the animals, comprising a nucleotide sequence encoding human FKBP51 operably linked to a tetracycline response element. In some embodiments, the transgenic animal comprises an additional transgenic nucleotide sequence, integrated into the genome of the animal, comprising a nucleotide sequence encoding a tetracycline transactivator (tTA) operably linked to a promoter wherein the tTA is expressed upon activation of the promoter and binds the tetracycline response element, thereby causing expression of FKBP51. The invention also pertains to methods for screening for agents for the prevention and/or treatment of psychiatric disorders, such as depression.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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