COMPOSITION PHARMACEUTIQUE AQUEUSE CONTENANT UN AGENT THERAPEUTIQUE BIOLOGIQUE ET DE LA GUANIDINE OU UN DERIVE DE GUANIDINE, ET INJECTION COMPRENANT LA COMPOSITION
The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection, particularly an intravitreal injection. The composition includes a biologic therapeutic agent (e.g., an isolated monoclonal antibody that specifically binds to a C5 protein) that tends to raise the viscosity of the composition and a guanidine and/or guanidine derivative (e.g., L-arginine) that tends to lower the viscosity of the composition.
