The present invention relates to the field of chemical and medicine, moreparticularly, 3-ethynylpyrazolopyrimidine derivatives and their preparationmethodsand uses. The invention provides a 3-ethynylpyrazolopyrimidine derivative, andthestructure is shown in formula I. The present invention also providespreparationmethods and use of 3-ethynylpyrazolopyrimidine derivatives, comprising thecompounds and derivatives, and their pharmaceutical compositions for the useof thetreatment and prevention of tumors.(see above formula)