LIGNEES CELLULAIRES, COMPOSITIONS LES RENFERMANT POUR LE TRAITEMENT DE MELANOMES, PROCEDES DE FABRICATION DE CES COMPOSITIONS ET METHODES DE TRAITEMENT
CONSEJO NACIONAL DE INVESTIGACIONES CIENTIFICAS Y TECNICAS (CONICET);INIS BIOTECH LLC;FUNDACION SALES
发明人:
MORDOH, JOSE,BARRIO, MARIA MARCELA,VON EUW, ERIKA MARIA
申请号：
CA2683629
公开号：
CA2683629C
申请日:
2008.04.11
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particularly, the invention relates to diverse human melanoma cell lines for the treatment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (deposited at German Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel-XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829), or (e) sub-populations thereof. The cell lines may be irradiated, thus obtaining populations with apoptotic phenotype, and populations with necrotic phenotype of such lines. The compositions may comprise adjuvants and/or immuno-modif iers, and/or autologous dendritic cells.
