A surgical system (300) comprises an ultrasonic surgical instrument (320) and a conduit (308,390). The conduit may be coupled with a vacuum source (306) and/or a fluid source (310). The instrument comprises an ultrasonic transducer (350), a waveguide (370), and an end effector (380). The waveguide extends fully through the transducer, such that a distal end of the waveguide is distal to the distal end of the transducer and such that a proximal end of the waveguide is proximal to the proximal end of the transducer. The waveguide is operable to transmit ultrasonic vibrations from the transducer to the end effector. The waveguide defines a lumen (372) in fluid communication with the conduit. The lumen is also in fluid communication with the end effector. The end effector may thus be used to deliver one or more of ultrasonic energy, suction, and/or fluid to a surgical site, in any suitable sequence or simultaneously.