A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, CLOBETASOLE PROPIONATE, TERBINAFINE HYDROCHLORIDE AND A PROCESS TO MAKE IT
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises Chitosan. Clobetasol Propionate, Terbinafine Hydrochloride and Fusidic acid. The invention also discloses a process to make the medicinal cream containing Fusidic Acid which is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic Acid under oxygen-free environment created using inert gas, preferably nitrogen, and Chitosan. The cream produced by the process of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic Acid. The cream produced by the process of the present invention contains Fusidic Acid as the API that has been formed in situ from Sodium Fusidate, Clobetasol Propionate and Terbinafine Hydrochloride in a cream base comprising a preservative, an acid, a co-solvent, an emulsifier and a waxy material along with water, preferably purified water.La présente invention concerne une composition médicinale destinée au traitement dinflammations cutanées, dinfections fongiques/bactériennes de la peau et des plaies associées et également dautres lésions cutanées y compris celles provoquées par des brûlures. La crème provoque également une réjuvénation cutanée par lintermédiaire dun processus dépithélialisation. La crème comprend du chitosane, du propionate de clobétasol, du chlorhydrate de terbinafine et de lacide fusidique. Linvention a également pour objet un procédé de fabrication de la crème médicinale contenant de lacide fusidique qui se forme in situ à partir de fusidate de sodium en tant que matière première de départ, ledit fusidate de sodium étant converti en acide fusidique dans un environnement dépourvu doxygène
