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A MEDICINAL FUSIDIC ACID CREAM MADE USING SODIUM FUSIDATE AND INCORPORATING A BIOPOLYMER, A CORTICOSTEROID - HYDROCORTISONE ACETATE, AND AN ANTIFUNGAL AGENT - TERBINAFINE HYDROCHLORIDE, AND A PROCESS TO MAKE IT
专利权人:
VANANGAMUDI; Sulur; Subramaniam
发明人:
VANANGAMUDI, Sulur, Subramaniam,SRINIVASAN, Madhavan,CHULLIEL, Neelakandan, Narayanan,HARIDAS, Sankar
申请号:
IBIB2011/053407
公开号:
WO2012/023082A1
申请日:
2011.08.01
申请国别(地区):
WO
年份:
2012
代理人:
摘要:
The present invention is directed to a medicinal composition for treating skin inflammations, fungal/bacterial skin infections and related wounds, and also other skin wounds including those caused by burns. The cream also causes skin rejuvenation through an epithelisation process. The cream comprises Chitosan. Hydrocortisone acetate, Terbinafine Hydrochloride and Fusidic acid. The invention also discloses a process to make the medicinal cream containing Fusidic Acid which is formed in situ from Sodium Fusidate as the starting raw material, wherein Sodium Fusidate is converted into Fusidic Acid under oxygen-free environment created using inert gas, preferably nitrogen, and Chitosan. The cream produced by the process of the present invention has greater shelf-life stability and the finer particle size of the API than the conventional creams containing Fusidic Acid. The cream produced by the process of the present invention contains Fusidic Acid as the API that has been formed in situ from Sodium Fusidate, Hydrocortisone acetate and Terbinafine Hydrochloride in a cream base comprising a preservative, an acid, a co-solvent, an emulsifier and a waxy material along with water, preferably purified water.La présente invention concerne une composition médicamenteuse permettant de traiter des inflammations cutanées, des infections cutanées fongiques/bactériennes et des plaies associées, ainsi que dautres plaies cutanées comprenant celles causées par des brûlures. Ladite crème induit également une réjuvénation cutanée par le biais dun processus dépithélisation. Ladite crème comprend du chitosane, de lacétate dhydrocortisone, du chlorhydrate de terbinafine et de lacide fusidique. Linvention concerne également un procédé de préparation de ladite crème médicamenteuse contenant de lacide fusidique préparé in situ avec du fusidate de sodium comme matière première de départ, lequel fusidate de sodium est transformé en acide fusidique dans un environnement exempt doxygène créé à laid
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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