Described are compositions and agents for blocking serum and other aging factors, especially arNOX in serum, skin or other body fluid or tissue and/or on the cell surface, and methods for using the same. More particularly, the invention relates to agents comprising any one of several naturally-occurring arNOX inhibitors capable of reducing occurrence or severity of or treating disorders and complications of disorders resulting from cell damage caused by aging-related isoforms of NADH oxidase (arNOX). In one exemplary embodiment, nutraceutical, cosmeceutical or pharmaceutical compositions comprise at least one naturally occurring arNOX inhibitor or inhibitor source. Such naturally occurring inhibitors also are capable of augmenting the anti-arNOX effect of other naturally occurring arNOX inhibitory agents. The discovery of multiple inhibitors with significantly different kinetics of inhibition that when combined provide long term arNOX inhibition is one of the unique and non-obvious features of the present methods and compositions.
