DIAS JOAO,CERULLO VINCENZO,HEMMINKI AKSELI,PESONEN SARI
申请号：
ZA201302429
公开号：
ZA201302429B
申请日:
2013.04.04
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to cancer therapies. More specifically, the present invention relates to oncolytic adenoviral vectors and cells and pharmaceutical compositions comprising said vectors. The present invention also relates to said vectors for treating cancer in a subject and a method of treating cancer in a subject. Furthermore, the present invention relates to methods of producing monoclonal anti-CTLA4 antibodies in a cell and increasing tumor specific immune response and apoptosis in a subject, as well as uses of the oncolytic adenoviral vectors for producing monoclonal anti-CTLA4 antibodies in a cell and increasing tumor specific immune response and apoptosis in a subject.
