The current research is on the potentiator of MC8324 receiver.A derivative of a herbicide was found to have a lethal effect on MC832424 receivers.This is a supplement to this application. The current herbicide is an acute response of MC832424 receptor, which can be used to prevent or treat bladder and/or urinary tract diseases.Especially,HypobladderHypotensive bladderNon-infectious bladderSide effects of DetroitNeurogenic bladderUretral's relaxation failedExternal urethral sphincter deoxygenation and benign prostatic hyperplasia disorder. 1. Requirement 1: a formula (1) or a salt,(There,A ring A represents a formula compound (2)；R1 represents any place where C83216C8331832626 can be replaced.E. Replaceable C8323883288 cyclo or replaceable saturated anisotropic ring；7.7491 and 7.7495 are the same or different.Each representative H or C 83218331832626 may be replaced.R.74919 and R.74959 do not represent H at the same time.If 74919 and R74955 are associated with the same carbon,749191,7.74959 R2 and its associated carbon atoms can form a saturated hydrocarbon ring together.R3 unite represents C8321C8331832626 asphalt, which can be replaced.E. Cyoquilo C83232383318328 may be replaced or phenyl may be replaced.R8308； 74919 stands for H.1. C83218331 and 832626 leased land；- C(o) R8313 O-S(o) 83228333；R8308； (74959) on behalf of H or lessor C83217C8331832626；X stands for CR831222 or N；R83099,R8310,R8311th,R831222 is the same or different.Everyone represents H or halogen.R83313 means C83218331832626 is irreplaceable or C832383318328；N stands for 0 or 1.En la presente se estudiaron los agonistas del receptor MC₄, y se ha descubierto que un derivado de piperazina tiene una acción agonista del receptor MC₄, con lo cual se completa la presente solicitud. El derivado de piperazina de la presente tiene una acción agonista del receptor MC₄ y puede usarse como agente para prevenir o tratar enfermedades de vejiga y/o tracto urinario, en particular, vejiga hipoactiva, vejiga hipotóni
